Thalidomide-Piperazine-PEG2-COOH

Thalidomide-Piperazine-PEG2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2797430-20-5]

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-piperazine-peg2-cooh.html

Purity

99.79

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC(N4CCN(CC4)CCOCCOCCC(O)=O)=CC=C31)=O

Molecular Formula

C24H30N4O8

Molecular Weight

502.52

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-992.