L-Thyroxine (sodium salt pentahydrate)

L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine, T3) from L-Thyroxine (T4) [1].

Product Specifications

CAS Number

[6106-07-6]

Product Name Alternative

Sodium levothyroxine pentahydrate

UNSPSC

12352005

Hazard Statement

H372

Target

Endogenous Metabolite; Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/L-Thyroxine-sodium-salt-pentahydrate.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : ≥ 28 mg/mL|H2O : < 0.1 mg/mL

Smiles

N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(O)C(I)=C2)C(O[Na])=O.O.O.O.O.O

Molecular Formula

C15H20I4NNaO9

Molecular Weight

888.93

Precautions

H372

References & Citations

[1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65 (3) :317-323.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.