Exatecan analogue 1
Exatecan analogue 1 (Icp-3) is a Exatecan (HY-13631) analogue. Exatecan analogue 1 can be used in the synthesis of antibody-drug conjugates (ADCs) [1]
Product Specifications
CAS Number
[2671770-58-2]
UNSPSC
12352203
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-analogue-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC(F)=C5N)=CC6=C1COC([C@]6(O)CC)=O
Molecular Formula
C23H20FN3O4
Molecular Weight
421.42
References & Citations
[1]Robert Yongxin Zhao, et al. Bcma monoclonal antibody and the antibody-drug conjugate. WO2023078021 A1. 2023-05-11.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Camptothecins
Curated Selection
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