Exatecan analogue 1

Exatecan analogue 1 (Icp-3) is a Exatecan (HY-13631) analogue. Exatecan analogue 1 can be used in the synthesis of antibody-drug conjugates (ADCs) [1]

Product Specifications

CAS Number

[2671770-58-2]

UNSPSC

12352203

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/exatecan-analogue-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC(F)=C5N)=CC6=C1COC([C@]6(O)CC)=O

Molecular Formula

C23H20FN3O4

Molecular Weight

421.42

References & Citations

[1]Robert Yongxin Zhao, et al. Bcma monoclonal antibody and the antibody-drug conjugate. WO2023078021 A1. 2023-05-11.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Camptothecins

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