Imidafenacin
Imidafenacin (KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors.
Product Specifications
CAS Number
[170105-16-5]
Product Name Alternative
KRP-197; ONO-8025
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Imidafenacin.html
Purity
99.32
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3C(C)=NC=C3)=O
Molecular Formula
C20H21N3O
Molecular Weight
319.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4- (1-Imidazolyl) -2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7 (6) :1151-61.|[2]Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386 (12) :1095-102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR3
Available Sizes
Curated Selection
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