ZTA-261
ZTA-261 is a highly selective and low toxic thyroid hormone receptor β subtype (THR-β) agonist (IC50=6.3 nM) that reduces body weight and visceral fat through a liothyronine mediated pathway. ZTA-261 can be used in the study of lipid metabolism and obesity prevalence[1].
Product Specifications
CAS Number
3049368-51-3
UNSPSC
12352005
Target
Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/zta-261.html
Purity
99.94
Smiles
O=C(CC1=CC(C(F)(F)F)=C(CC2=CC=C(C3=C2C=CC=C3)O)C(C(F)(F)F)=C1)O
Molecular Formula
C21H14F6O3
Molecular Weight
428.32
References & Citations
[1]Nambo, et al. "Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261." Communications Medicine 4.1 (2024) : 152.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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