Anti-α-1-antitrypsin Antibody

Mouse Monoclonal Antibody specific to α-1-antitrypsin

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

α-1 protease inhibitor, α-1-antiproteinase, Serpin A1 [Cleaved into: Short peptide from AAT

Gene Name

SERPINA1

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=SERPINA1">SERPINA1</a>

UniProt

P01009

Cellular Locus

Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.; [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix.

Host

Mouse

Reactivity

Human

Immunogen

Purified human serum alpha-1-antitrypsin.

Target Antigen

α-1-antitrypsin

Target

α-1-antitrypsin

Clonality

Monoclonal

Isotype

IgG2a

Type

Antibody

Applications

ELISA

Field of Research

Enzymes

Purification Method

Purified by protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Additionnal Information

These antibodies have been qualified for use in ELISA to detect human a1AT. <br><br>End users should determine optimal concentrations for their applications.