Maleimide-PEG8-Val-Ala-PAB-SNS032
Maleimide-Val-Ala-PAB-SNS032 is a conjugate of ADC toxin and linker. SNS032 is an inhibitor for CDK, inhibiting the cell cycle at G1/S phase and cell viability of cancer cells. Maleimide-Val-Ala-PAB is a cleavable ADC linker. Maleimide-Val-Ala-PAB-SNS032 can be utilized for the synthesis of ADC molecules[1].
Product Specifications
UNSPSC
12352203
Target
CDK; Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/maleimide-peg8-val-ala-pab-sns032.html
Smiles
O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(COC(N3CCC(C(NC4=NC=C(SCC5=NC=C(C(C)(C)C)O5)S4)=O)CC3)=O)C=C2)=O)=O)=O)=O
Molecular Formula
C59H87N9O18S2
Molecular Weight
1274.50
References & Citations
[1]Cheung A, et al., Anti-EGFR antibody-drug conjugate carrying an inhibitor targeting CDK restricts triple-negative breast cancer growth. Clin Cancer Res. 2024 May 21.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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