[pSer2, pSer5, pSer7]-CTD

[pSer2, pSer5, pSer7]-CTD, a substrate for CDK7 (cyclin dependent protein kinase), is a phosphorylated polypeptide at ser2, ser5 and ser7 sites of RNA polymerase II carboxy-terminal domain (CTD) [1].

Product Specifications

UNSPSC

12352209

Target

CDK

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pser2-pser5-pser7-ctd.html

Solubility

H2O

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](COP(O)(O)=O)NC([C@H]2N(CCC2)C([C@H](COP(O)(O)=O)NC([C@H]([C@H](O)C)NC([C@H]3N(CCC3)C([C@H](COP(O)(O)=O)NC([C@@H](N)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(N5[C@@H](CCC5)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N7[C@@H](CCC7)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N8[C@@H](CCC8)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)CC9=CC=C(C=C9)O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C96H140N21O46P3

Molecular Weight

2417.17

References & Citations

[1]Czudnochowski N, et al. Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition. Nat Commun. 2012 May 15;3:842.