AZD5582 (dihydrochloride)

AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis[1].

Product Specifications

CAS Number

[1883545-51-4]

UNSPSC

12352005

Target

Apoptosis; IAP

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azd5582-dihydrochloride.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CN[C@@H](C)C(N[C@H](C(N1[C@H](C(N[C@H]2C3=CC=CC=C3C[C@H]2OCC#CC#CCO[C@H]4[C@@H](NC([C@@H]5CCCN5C([C@@H](NC([C@H](C)NC)=O)C6CCCCC6)=O)=O)C(C=CC=C7)=C7C4)=O)CCC1)=O)C8CCCCC8)=O.Cl.Cl

Molecular Formula

C58H80Cl2N8O8

Molecular Weight

1088.21

References & Citations

[1]Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582) . J Med Chem. 2013 Dec 27;56 (24) :9897-919.|[2]Qin Hao, et al. IF-γ and Smac mimetics synergize to induce apoptosis of lung cancer cells in a TNFα-independent manner, Cancer Cell Int. 2018; 18: 84.