C6 NBD Glucosylceramide

C6 NBD Glucosylceramide is a glucosylceramide fluorescent derivative (Ex=466 nm, Em=535 nm) . C6 NBD Glucosylceramide can be used to study the metabolism and internalization of glucosylceramide and also for the determination of glucosyl ceramide synthase activity[1][2][3].

Product Specifications

CAS Number

[94885-03-7]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/c6-nbd-glucosylceramide.html

Purity

98.00

Solubility

10 mM in DMSO

Smiles

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCNC2=CC=C([N+]([O-])=O)C3=NON=C23)=O

Molecular Formula

C36H59N5O11

Molecular Weight

737.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Kok JW, et al. Salvage of glucosylceramide by recycling after internalization along the pathway of receptor-mediated endocytosis. Proc Natl Acad Sci U S A. 1989 Dec;86 (24) :9896-900. |[2]Hayashi Y, et al. A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates. Anal Biochem. 2005 Oct 15;345 (2) :181-6. |[3]di Bartolomeo S, et al. Differential chemosensitizing effect of two glucosylceramide synthase inhibitors in hepatoma cells. Biochem Biophys Res Commun. 2001 Oct 19;288 (1) :269-74.