GW-406381
Product Specifications
Product Name Alternative
Adonitol; Adonite
UNSPSC Description
GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury[1][2].
Target Antigen
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gw-406381.html
Purity
99.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C=C1)C2=C3C=CC=NN3N=C2C4=CC=C(C=C4)OCC)(C)=O
Molecular Weight
393.46
References & Citations
[1]Zhao FY, et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain. 2007 Mar;128(1-2):78-87.|[2]Boswell DJ, et al. Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Medscape J Med. 2008;10(11):259.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119304/GW-406381-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119304/GW-406381-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
221148-46-5
Available Sizes
Curated Selection
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