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2,2′-Dihydroxychalcone

2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties[1][2].

Product Specifications

CAS Number

15131-80-3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Glutathione S-transferase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-2-dihydroxychalcone.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1O)C=CC2=CC=CC=C2O

Molecular Formula

C15H12O3

Molecular Weight

240.25

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ahmed Q Haddad, et al. Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr Cancer. 2010;62 (5) :668-81. |[2]Kenneth Goh, et al. 2,2'-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D. Mol Med Rep. 2008 Jul-Aug;1 (4) :575-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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