INOs-IN-1

INOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/inos-in-1.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=C(C=C4)O

Molecular Formula

C25H28N4O5

Molecular Weight

464.51

References & Citations

[1]Peng Y, et al. Identification and molecular mechanism of a tri-peptide inhibitor targeting iNOS from duck embryo protein hydrolysates by experimental and bioinformatics studies. Bioorg Chem. 2022;122:105736.