Cd1a
Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Cav2.2) (IC502.6 μM) and mouse sodium ion channels (Nav1.7) . Cd1a can be used in the development of peripheral pain treatment drugs [1].
Product Specifications
Product Name Alternative
β-TRTX-cd1a; β-Theraphotoxin-cd1a
UNSPSC
12352209
Target
Calcium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cd1a.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC(O)=O)=O)CC4=CC=C(O)C=C4)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCCCN)=O)CCC1)=O)CC(O)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)=O)CO)=O)CCCCN)=O)CC8=CC=CC=C8)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]5CO)=O)CC%11=CC=C(O)C=C%11)=O)CC(N)=O)=O)CCCCN)=O
Molecular Formula
C171H254N52O50S6
Molecular Weight
4030.55
References & Citations
[1]Sousa SR, et al. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12 (9) :e0182848.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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