Keap1-Nrf2-IN-19
Keap1-Nrf2-IN-19 (compound 33) is an oral active Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with the Kd value of 0.0014 μM. Keap1-Nrf2-IN-19 exhibits less than 50% inhibition at 30 μM against hERG and 10 μM against CYPs[1].
Product Specifications
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-19.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C(O)=O)[C@@H](C1=CC(OCC2(C#N)CC2)=C(C=C1)C)NC([C@H](C3=CC=C(C=C3)C)F)=O
Molecular Formula
C25H27FN2O4
Molecular Weight
438.49
References & Citations
[1]Otake K, et al. Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors. J Med Chem. 2024 Feb 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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