NPD6433
Product Specifications
UNSPSC Description
NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis[1].
Target Antigen
Fatty Acid Synthase (FASN); Fungal
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/npd6433.html
Smiles
O=C(C1=C(/N=N/N2C[C@@H]3C4=CC=CC(N4C[C@@H](C3)C2)=O)C5=C(C=CC=C5)N1)OC
Molecular Weight
391.42
References & Citations
[1]Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chem Biol. 2023 Jul 20;30(7):795-810.e8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-167879A/NPD6433-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-167879A/
Clinical Information
No Development Reported
Curated Selection
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