NPD6433

NPD6433 is a triazenyl indole with broad-spectrum activity against all screening fungal strains. NPD6433 targets the enoyl reductase domain of fatty acid synthase 1 (Fas1), covalently inhibiting its flavin mononucleotide-dependent NADPH-oxidation activity and arresting essential fatty acid biosynthesis[1].

Product Specifications

UNSPSC

12352005

Target

Fatty Acid Synthase (FASN) ; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/npd6433.html

Smiles

O=C(C1=C(/N=N/N2C[C@@H]3C4=CC=CC(N4C[C@@H](C3)C2)=O)C5=C(C=CC=C5)N1)OC

Molecular Formula

C21H21N5O3

Molecular Weight

391.42

References & Citations

[1]Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity. Cell Chem Biol. 2023 Jul 20;30 (7) :795-810.e8.