MGluR2 modulator 1

MGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC50 of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research[1].

Product Specifications

CAS Number

[2671063-84-4]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mglur2-modulator-1.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(CCN2C1=NC3=C2C=CC=C3)CCCCOC4=CC=C(C=C4)OC(F)(F)F

Molecular Formula

C21H20F3N3O3

Molecular Weight

419.40

References & Citations

[1]Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs) . Eur J Med Chem. 2020 Jan 15;186:111881.