Z-Gly-Gly-Arg-AMC

Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) [1][2].

Product Specifications

CAS Number

[66216-78-2]

UNSPSC

12171500

Target

Fluorescent Dye; Thrombin

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/z-gly-gly-arg-amc.html

Purity

99.90

Solubility

H2O : 40 mg/mL (ultrasonic; warming) |DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC(NCC(N[C@@H](CCCNC(N)=N)C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)=O)=O)OCC3=CC=CC=C3

Molecular Formula

C28H33N7O7

Molecular Weight

579.60

References & Citations

[1]Mothukuri GK, et al. Macrocycle synthesis strategy based on step-wise "adding and reacting" three components enables screening of large combinatorial libraries. Chem Sci. 2020 Jun 26;11 (30) :7858-7863. |[2]Tarandovskiy ID, et al. Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications. PLoS One. 2013;8 (2) :e55688. |[3]Machlus KR, et al. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009 Nov;102 (5) :936-44.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Citation 01

Int J Biol Macromol. 2019 Aug 1:134:622-630.|Int J Biol Macromol. 2019 Sep 15:137:261-269.|Phytochemistry. 2019 Sep:165:112025.|Acta Pharmacol Sin. 2024 Nov;45 (11) :2300-2312.|Bioorg Chem. 2019 Nov:92:103199.|Blood Adv. 2025 Mar 24:bloodadvances.2024015212.|Cell Rep Med. 2025 Aug 19;6 (8) :102260.|Chem Biol Interact. 2023 Jun 1:378:110501.|J Mater Chem B. 2017 Oct 14;5 (38) :7876-7884. |RSC Adv. 2020, 10 (7) :3626-3635.|Spectrochim Acta A Mol Biomol Spectrosc. 2022 Jan 5:264:120250.