Azoxymethane

Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.

Product Specifications

CAS Number

[25843-45-2]

Product Name Alternative

AOM

UNSPSC

12352211

Hazard Statement

H226, H300, H315, H319, H350

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Azoxymethane.html

Concentration

135 mM * 10 mL in Water

Purity

99.0

Solubility

H2O : ≥ 200 mg/mL

Smiles

C/[N+]([O-])=N/C

Molecular Formula

C2H6N2O

Molecular Weight

74.08

Precautions

H226, H300, H315, H319, H350

References & Citations

[1]Megaraj V, et al. Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice. Chem Res Toxicol. 2014 Apr 21;27 (4) :656-62.|[2]Whetstone RD, et al. Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate. Mol Carcinog. 2016 Jul;55 (7) :1187-95.|[3]Fichera A, et al. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res. 2007 Jan 15;67 (2) :827-35.