MS-553
MS-553 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.
Product Specifications
CAS Number
[1046787-18-1]
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PKC-IN-1.html
Concentration
10mM
Purity
99.79
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](C)CN(CC2CCOCC2)[C@H](C)C1)N(C3)C(C)(C)C4=C3C(NC5=NC(C)=NC=C5F)=NN4
Molecular Formula
C25H37FN8O2
Molecular Weight
500.61
References & Citations
[1]Michael Niesman, et al. Treatment of autoimmune disease. WO2015179847A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCα; PKCβ; PKCγ; PKCε; PKCθ; PKCμ
Available Sizes
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