MS-553

MS-553 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

Product Specifications

CAS Number

[1046787-18-1]

UNSPSC

12352005

Target

PKC

Type

Reference compound

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/PKC-IN-1.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](C)CN(CC2CCOCC2)[C@H](C)C1)N(C3)C(C)(C)C4=C3C(NC5=NC(C)=NC=C5F)=NN4

Molecular Formula

C25H37FN8O2

Molecular Weight

500.61

References & Citations

[1]Michael Niesman, et al. Treatment of autoimmune disease. WO2015179847A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PKCα; PKCβ; PKCγ; PKCε; PKCθ; PKCμ

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP1-78980CL1 0.1 mL

Rabbit Polyclonal CARD12 Antibody [CoraFluor 1]

Ask

View Details

MBS1059984-01 0.02 mg (E-Coli)

Recombinant Pyrococcus horikoshii Uncharacterized ZPR1-like protein PH1223 (PH1223)

Ask

View Details

MBS1059984-02 0.1 mg (E-Coli)

Recombinant Pyrococcus horikoshii Uncharacterized ZPR1-like protein PH1223 (PH1223)

Ask

View Details

MBS1059984-03 0.02 mg (Yeast)

Recombinant Pyrococcus horikoshii Uncharacterized ZPR1-like protein PH1223 (PH1223)

Ask

View Details

MBS1059984-04 0.1 mg (Yeast)

Recombinant Pyrococcus horikoshii Uncharacterized ZPR1-like protein PH1223 (PH1223)

Ask

View Details

MBS1059984-05 0.02 mg (Baculovirus)

Recombinant Pyrococcus horikoshii Uncharacterized ZPR1-like protein PH1223 (PH1223)

Ask

View Details