Anti-APRIL (ED) Antibody

Rabbit Polyclonal Antibody specific to APRIL (ED)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

A proliferation-inducing ligand, APRIL, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, TNF-related death ligand 1, TRDL-1, CD antigen CD256

Gene Name

TNFSF13

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFSF13">TNFSF13</a>

UniProt

O75888

Cellular Locus

Secreted

Host

Rabbit

Reactivity

Human, Drosophila

Immunogen

Peptide corresponding to aa 50-100 of human APRIL.

Target Antigen

Tumor necrosis factor ligand superfamily member 13

Target

APRIL (ED)

Clonality

Polyclonal

Type

Antibody

Applications

ELISA, WB

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {PubMed:10973284}.

Additionnal Information

Immunoblotting: use at 5-10 ug/mL. A band of ~27kDa is detected.

Storage Conditions

This antibody is stable for three months at 4°C and at least one year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

Human APRIL. Reactivity with other species has not been investigated.

Formulation

PBS, 0.02% sodium azide.

Target Background

APRIL (A Proliferation-Inducing Ligand) is a member of the TNF superfamily identified in human and mouse. Two receptors for APRIL have been designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its receptors BCMA and TACI are involved in autoimmunity and cancer.