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Gambogic Acid (Standard)

Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

Product Specifications

CAS Number

2752-65-0

Product Name Alternative

Beta-Guttiferrin (Standard)

UNSPSC

12352005

Target

Autophagy; Bcl-2 Family; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gambogic-acid-standard.html

Smiles

O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@@](C[C@@]2([H])C=C34)([H])[C@]31OC5=C(C(O)=C(C=C[C@](CC/C=C(C)/C)(C)O6)C6=C5C/C=C(C)\C)C4=O

Molecular Formula

C38H44O8

Molecular Weight

628.75

References & Citations

[1]Zhai D, et al. Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2008 Jun;7 (6) :1639-46.|[2]Wang LH, et al. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling. Br J Cancer. 2014 Jan 21;110 (2) :341-52.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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