Anti-inflammatory agent 78
Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
COX; PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-78.html
Solubility
10 mM in DMSO
Smiles
OC(C1=CC=C(Cl)C=C1N2CC3=CC=CC=C3)(C#CC(OC)=O)C2=O
Molecular Formula
C19H14ClNO4
Molecular Weight
355.77
References & Citations
[1]Akhtar M, et al. A series of indole-derived γ-hydroxy propiolate esters as potent anti-inflammatory agents: Design, synthesis, in-vitro and in-vivo biological studies. Eur J Med Chem. 2024 Apr 15;270:116376.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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