Anti-inflammatory agent 78

Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

COX; PGE synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-78.html

Solubility

10 mM in DMSO

Smiles

OC(C1=CC=C(Cl)C=C1N2CC3=CC=CC=C3)(C#CC(OC)=O)C2=O

Molecular Formula

C19H14ClNO4

Molecular Weight

355.77

References & Citations

[1]Akhtar M, et al. A series of indole-derived γ-hydroxy propiolate esters as potent anti-inflammatory agents: Design, synthesis, in-vitro and in-vivo biological studies. Eur J Med Chem. 2024 Apr 15;270:116376.