HCoV-OC43 Nucleocapsid protein, His Tag
HCoV-OC43 Nucleocapsid, His Tag (NUN-V5145) is expressed from E. coli cells. It contains AA Met 1 - Ile 448 (Accession # P33469-1) .
Product Specifications
Background
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68) . The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 50.3 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) .
Accession Number
P33469-1
Expression Region
Met 1 - Ile 448
Host
E. coli
Target
Nucleocapsid protein
Conjugation
Unconjugated
Tag
N-6xHis
Source
HCoV-OC43
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
40 mM PB, 500 mM NaCl, pH7.4
Additives
Trehalose
Molecular Weight
50.3 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
200ug*5
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/NUN-V5145.pdf
Species
HCoV-OC43
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