Orvepitant

Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist.

Product Specifications

CAS Number

[579475-18-6]

Product Name Alternative

GW823296

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/orvepitant.html

Smiles

C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N(C)C(N2[C@@H](C3=C(C=C(C=C3)F)C)C[C@@H](N4C[C@@]5([H])N(C(CC5)=O)CC4)CC2)=O

Molecular Formula

C31H35F7N4O2

Molecular Weight

628.62

References & Citations

[1]Neurokinin-1 antagonist orvepitant for EGFRI-induced pruritus in patients with cancer: a randomised, placebo-controlled phase II trial

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

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