(9R,12aR) -AZD4747
(9R,12aR) -AZD4747 is a diastereomer of AZD4747. AZD4747 is a selective mutant GTPase KRASG12C inhibitor with blood-brain barrier permeability. AZD4747 has the potential to study cancer[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/9r-12ar-azd4747.html
Purity
98.90
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
C=CC(N(C[C@@H]1COC2=C3F)CCN1CC2=CC(C#CC)=[C@@]3[C@]4=C(C=CC=C4O)Cl)=O
Molecular Formula
C24H22ClFN2O3
Molecular Weight
440.89
References & Citations
[1]Kettle JG, et al. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration. J Med Chem. 2023 Jul 13;66 (13) :9147-9160.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680050-100 1x 100 µL
IgA Secretory Component (SC05), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880806-500 1x 500 µL
TYRP1 (Tyrosinase Related Protein 1) (TA99), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470253-100 1x 100 µL
Cytokeratin, LMW (AE-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470977-100 1x 100 µL
TGF-beta (1D11.16.8), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880012-500 1x 500 µL
Tyrosinase (T311), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details