Brophenexin
Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
Product Specifications
CAS Number
[2243506-33-2]
Product Name Alternative
NMDAR/TRPM4-IN-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
ERK; iGluR; TRP Channel
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmdar-trpm4-in-2.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
NCCN(CC1=CC=CC(Br)=C1)CC.[H]Cl.[H]Cl
Molecular Formula
C11H19BrCl2N2
Molecular Weight
330.09
Precautions
H315, H319, H320
References & Citations
[1]Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370 (6513) :eaay3302.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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