Brophenexin
Product Specifications
UNSPSC Description
Brophenexin (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin shows neuroprotective activity. Brophenexin prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
Target Antigen
ERK; iGluR; TRP Channel
Type
Reference compound
Related Pathways
MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Neuronal Signaling;Stem Cell/Wnt
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmdar-trpm4-in-2.html
Smiles
NCCN(CC1=CC=CC(Br)=C1)CC.[H]Cl.[H]Cl
Molecular Weight
330.09
References & Citations
[1]Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513):eaay3302.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139192/Brophenexin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139192/NMDAR-TRPM4-IN-2-SDS-MedChemExpress.pdf
CAS Number
2243506-33-2
Available Sizes
Curated Selection
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