PNU-145156E

Product Specifications

UNSPSC Description

PNU-145156E (FCE26644) is an angiogenesis inhibitor with anti-tumor activity. PNU-145156E inhibits the binding of bFGF to its receptor and inhibits bFGF-induced endothelial cell proliferation and motility[1].

Target Antigen

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pnu-145156e.html

Smiles

O=C(NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CC4=C(S(=O)(O[Na])=O)C=C(S(=O)(O[Na])=O)C=C4C=C3)=O)=C2)=O)=C1)NC5=CN(C)C(C(NC6=CN(C)C(C(NC7=CC8=C(S(=O)(O[Na])=O)C=C(S(=O)(O[Na])=O)C=C8C=C7)=O)=C6)=O)=C5

Molecular Weight

1209.04

References & Citations

[1]Groen H J M, et al. PNU-145156E, a novel angiogenesis inhibitor, in patients with solid tumors: a phase I and pharmacokinetic study[J]. Clinical cancer research, 2001, 7(12): 3928-3933.