PNU-145156E
PNU-145156E (FCE26644) is an angiogenesis inhibitor with anti-tumor activity. PNU-145156E inhibits the binding of bFGF to its receptor and inhibits bFGF-induced endothelial cell proliferation and motility[1].
Product Specifications
CAS Number
154788-16-6
Product Name Alternative
FCE26644
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pnu-145156e.html
Smiles
O=C(NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CC4=C(S(=O)(O[Na])=O)C=C(S(=O)(O[Na])=O)C=C4C=C3)=O)=C2)=O)=C1)NC5=CN(C)C(C(NC6=CN(C)C(C(NC7=CC8=C(S(=O)(O[Na])=O)C=C(S(=O)(O[Na])=O)C=C8C=C7)=O)=C6)=O)=C5
Molecular Formula
C45H36N10Na4O17S4
Molecular Weight
1209.04
References & Citations
[1]Groen H J M, et al. PNU-145156E, a novel angiogenesis inhibitor, in patients with solid tumors: a phase I and pharmacokinetic study[J]. Clinical cancer research, 2001, 7 (12) : 3928-3933.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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