GLX351322

GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.

Product Specifications

CAS Number

[835598-94-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NADPH Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/GLX351322.html

Purity

99.48

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(OCC)C1=C(SC2=C1CCC2)NC(CN3CCN(CC3)C(C4=CC=CO4)=O)=O

Molecular Formula

C21H25N3O5S

Molecular Weight

431.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49 (11) :1308-18.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NOX4

Available Sizes

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