GLX351322
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.
Product Specifications
CAS Number
[835598-94-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NADPH Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/GLX351322.html
Purity
99.48
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(OCC)C1=C(SC2=C1CCC2)NC(CN3CCN(CC3)C(C4=CC=CO4)=O)=O
Molecular Formula
C21H25N3O5S
Molecular Weight
431.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49 (11) :1308-18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOX4
Available Sizes
Curated Selection
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