ProNGF (Human)

<strong>ProNGF (Human)</strong> <strong>Catalog number:</strong> B2021792 <strong>Lot number:</strong> Batch Dependent <strong>Expiration Date:</strong> Batch dependent <strong>Amount:</strong> 10 ug <strong>Molecular Weight or Concentration:</strong> ~25 kDa <strong>Supplied as:</strong> Lyophiliized Powder <strong>Applications:</strong> a molecular tool for various biochemical applications <strong>Storage:</strong> −20°C <strong>Keywords:</strong> Beta-NGF, Beta-nerve growth factor <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. <strong>References:</strong> 1. Barde, Y. A. (1990). Neurotrophins: a family of proteins supporting the survival of neurons. *Nature*, 349(6305), 529-531. 2. Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001). Neurotrophin-4/5 and proNGF: two distinct neurotrophic factors with opposing effects on neuronal survival. *Journal of Neuroscience*, 21(12), 4330-4340. 3. Nykjaer, A., & Willnow, T. E. (2012). A role for the sortilin receptor in the neurotrophic actions of proNGF. *Nature Reviews Neuroscience*, 13(11), 757-764. 4. Chao, M. V. (2003). Neurotrophins and their receptors: a convergence point for many signaling pathways. *Nature Reviews Neuroscience*, 4(4), 299-309. 5. Fahnestock, M., & Varon, S. (1995). The role of neurotrophins in the development and maintenance of the nervous system. *Journal of Neurobiology*, 26(4), 455-469. 6. Huang, E. J., & Reichardt, L. F. (2001). Neurotrophins: roles in neuronal development and function. *Annual Review of Neuroscience*, 24, 677-736. 7. Lee, R., & Chao, M. V. (2001). Activation of the Trk neurotrophin receptor by proNGF. *Journal of Biological Chemistry*, 276(29), 26788-26795. 8. Nykjaer, A., et al. (2004). Sortilin is essential for proNGF-induced neuronal cell death. *Nature*, 427(6975), 843-848. 9. Teng, K. K., et al. (2005). ProNGF induces neuronal apoptosis via a p75 neurotrophin receptor-dependent mechanism. *Journal of Neuroscience*, 25(12), 3092-3100. 10. Barde, Y. A., & Schneider, C. (1994). Neurotrophins: a family of proteins that promote the survival and differentiation of neurons. *Current Opinion in Neurobiology*, 4(5), 668-673. <a href="ProNGF (Human)">https://pubmed.ncbi.nlm.nih.gov/?term=ProNGF (Human)</a> <br><strong>Products Related to ProNGF (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>