[pTyr5] EGFR (988-993) (TFA)

[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993) . [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) [1].

Product Specifications

UNSPSC

12352209

Target

Phosphatase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ptyr5-egfr-988-993-tfa.html

Solubility

10 mM in DMSO

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C33H46F3N6O19P

Molecular Weight

918.72

References & Citations

[1]Sarmiento M, et al. Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry. 2000 Jul 18;39 (28) :8171-9.