DOTAGA-anhydride

DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs) . DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907) ) . DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging[1].

Product Specifications

CAS Number

[1375475-53-8]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Biochemical Assay Reagents; Radionuclide-Drug Conjugates (RDCs)

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dotaga-anhydride.html

Purity

99.80

Solubility

DMSO : 70 mg/mL (ultrasonic)

Smiles

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1

Molecular Formula

C19H30N4O9

Molecular Weight

458.46

Precautions

H315, H319

References & Citations

[1]Bernhard C, et al. DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents. Chemistry. 2012 Jun 18;18 (25) :7834-41.