DOTAGA-anhydride
Product Specifications
UNSPSC Description
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.
Target Antigen
EGFR; Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/dotaga-anhydride.html
Purity
99.80
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1
Molecular Weight
458.46
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, stored under nitrogen
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W087187/DOTAGA-anhydride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W087187/
Clinical Information
No Development Reported
CAS Number
1375475-53-8
Available Sizes
Curated Selection
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