Mycophenolate mofetil (hydrochloride)

Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.

Product Specifications

CAS Number

[116680-01-4]

Product Name Alternative

RS 61443 (hydrochloride) ; TM-MMF (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mycophenolate-mofetil-hydrochloride.html

Purity

99.17

Solubility

10 mM in DMSO

Smiles

O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC.Cl

Molecular Formula

C23H32ClNO7

Molecular Weight

469.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Nakanishi, T., et al., Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol, 2010. 10 (1) : p. 91-7.|[2]Dehghani, F., et al., Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil. Neuropathol Appl Neurobiol, 2010. 36 (7) : p. 598-611.|[3]Ozgen, M., et al., Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-induced experimental scleroderma. Clin Exp Dermatol, 2012. 37 (1) : p. 48-54.