L-NIO (dihydrochloride)

L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively[1][2]. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats[2].

Product Specifications

CAS Number

[159190-44-0]

UNSPSC

12352211

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/L-NIO_dihydrochloride.html

Purity

97.0

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

N[C@@H](CCCNC(C)=N)C(O)=O.[H]Cl.[H]Cl

Molecular Formula

C7H17Cl2N3O2

Molecular Weight

246.13

References & Citations

[1]Babu BR, et al. N5- (1-Imino-3-butenyl) -L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273 (15) :8882-9.|[2]Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.