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Sertaconazole (nitrate) (Standard)

Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate) . This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells[1][2][3][4].

Product Specifications

CAS Number

99592-39-9

Product Name Alternative

FI7056 (Standard)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Fungal; Microtubule/Tubulin; p38 MAPK; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway; Others

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sertaconazole-nitrate-standard.html

Smiles

ClC1=CC=C(C(OCC2=CSC3=C(Cl)C=CC=C32)CN4C=CN=C4)C(Cl)=C1.O[N+]([O-])=O

Molecular Formula

C20H16Cl3N3O4S

Molecular Weight

500.78

References & Citations

[1]Carrillo-Muñoz AJ, et al. In-vitro antifungal activity of sertaconazole, econazole, and bifonazole against Candida spp. J Antimicrob Chemother. 1995 Oct;36 (4) :713-6.|[2]Sur R, et al. Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway. J Invest Dermatol. 2008 Feb;128 (2) :336-44.|[3]Sebastian J, et al. Sertaconazole induced toxicity in HeLa cells through mitotic arrest and inhibition of microtubule assembly. Naunyn Schmiedebergs Arch Pharmacol. 2021 Jun;394 (6) :1231-1249.|[4]Zhang W, et al. Sertaconazole provokes proapoptotic autophagy via stabilizing TRADD in nonsmall cell lung cancer cells. MedComm (2020) . 2021 Dec 16;2 (4) :821-837.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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