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PPC-NB

PPC-NB is a glutathione cleavable linker used for the antibody-drug conjugate (ADC) [1].

Product Specifications

CAS Number

1887040-81-4

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ppc-nb.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC(SSC1=NC=CC=C1)C)OC2=CC=C([N+]([O-])=O)C=C2

Molecular Formula

C15H14N2O5S2

Molecular Weight

366.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Robert A. Volkmann, et al. Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues. WO2019136298A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Disulfide Cleavable Linker

Available Sizes

Frequently Asked Questions

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