PPC-NB
PPC-NB is a glutathione cleavable linker used for the antibody-drug conjugate (ADC) [1].
Product Specifications
CAS Number
[1887040-81-4]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ppc-nb.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC(SSC1=NC=CC=C1)C)OC2=CC=C([N+]([O-])=O)C=C2
Molecular Formula
C15H14N2O5S2
Molecular Weight
366.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Robert A. Volkmann, et al. Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues. WO2019136298A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Disulfide Cleavable Linker
Available Sizes
Curated Selection
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