11β-HSD1-IN-14

11β-HSD1-IN-14 (Compound 17) is a selective inhibitor for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1), with IC50 of 74 nM for human HSD1, and 603 nM for HSD1 expressed HEK293 cell[1].

Product Specifications

CAS Number

[946394-50-9]

UNSPSC

12352005

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/11β-hsd1-in-14.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N3CCN(CC3)C4=NC=CC=C4C(F)(F)F)=O

Molecular Formula

C22H20F3N3O2S

Molecular Weight

447.47

References & Citations

[1]Sun D, et al., Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) . Bioorg Med Chem Lett. 2008 Jun 15;18 (12) :3513-6.