Cortistatin-29 (rat)
Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects[1][2][3][4].
Product Specifications
CAS Number
1815618-17-7
UNSPSC
12352209
Target
Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cortistatin-29-1.html
Smiles
O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)CO)=O)CO)=O)C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H]3N(CCC3)C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC4=CN=CN4)NC([C@H]5N(CCC5)C([C@H]6N(CCC6)C([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H]7N(CCC7)C([C@H]8N(CCC8)C([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC([C@@H]9CCC(N9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCCCN)=O)CC(N)=O)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=CC=C%11)N[C@H]1CC%12=CNC%13=CC=CC=C%12%13.OC(C(F)(F)F)=O.[x]
Molecular Formula
C161H240N46O41S2
Molecular Weight
3540.04
References & Citations
[1]Falo CP, et al. The Neuropeptide Cortistatin Alleviates Neuropathic Pain in Experimental Models of Peripheral Nerve Injury. Pharmaceutics. 2021 Jun 24;13 (7) :947.|[2]Baranowska B, et al. Direct effect of cortistatin on GH release from cultured pituitary cells in the rat. Neuro Endocrinol Lett. 2006 Feb-Apr;27 (1-2) :153-6.|[3]Spier AD, et al. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev. 2000 Sep;33 (2-3) :228-41.|[4]Benitez R, et al. Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury. Br J Pharmacol. 2022 May;179 (10) :2275-2296.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
SSTR1; SSTR2; SSTR3; SSTR4; SSTR5
Frequently Asked Questions
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