Phospho-Cofilin (S3) Recombinant Rabbit Monoclonal Antibody [PSH07-18]
Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Cofilin-1 18 kDa phosphoprotein (p18) Cofilin, non-muscle isoform CFL1 CFL
Swiss Prot
P23528 Human, P45592 Rat
Cellular Locus
Nucleus matrix, Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, lamellipodium membrane, lamellipodium, growth cone, axon.
Host
Rabbit
Species Reactivity
Human,Rat,Monkey
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser3 of human Cofilin aa 1-50.
Isotype
IgG
Clone
PSH07-18
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
COS-1 cell lysate, C6 cell lysate, Jurkat cell lysate, MCF7 cell lysate, A431 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:2,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 19 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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