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UCSF924

UCSF924, a chemical probe, is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has no off-target effects on more than 320 non-olfactory GPCRs. UCSF924 can be used for research in the field of neuropsychiatric diseases[1][2].

Product Specifications

CAS Number

1434515-70-4

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ucsf924.html

Purity

99.53

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC(CNCCCOC2=CC=CC=C2)=NC3=CC=C(C)C=C13

Molecular Formula

C20H22N2O2

Molecular Weight

322.40

References & Citations

[1]Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358 (6361) :381-386.|[2]Thomas G E. Characterizing antipsychotic behavioral and corticostriatal neurophysiological effects to psychotomimetic challenge. Duke University, 2022.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

D4 Receptor

Available Sizes

Frequently Asked Questions

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