KX2-361

KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].

Product Specifications

CAS Number

[897016-26-1]

Product Name Alternative

KX-02

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Src

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kx2-361.html

Purity

99.55

Solubility

DMSO : 10.71 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCC1=CC=CC(F)=C1)CC2=NC=C(C3=CC=C(N4CCOCC4)C=C3)C=C2

Molecular Formula

C24H24FN3O2

Molecular Weight

405.46

References & Citations

[1]Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140 (3) :519-527.