KX2-361
KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].
Product Specifications
CAS Number
[897016-26-1]
Product Name Alternative
KX-02
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Src
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kx2-361.html
Purity
99.55
Solubility
DMSO : 10.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCC1=CC=CC(F)=C1)CC2=NC=C(C3=CC=C(N4CCOCC4)C=C3)C=C2
Molecular Formula
C24H24FN3O2
Molecular Weight
405.46
References & Citations
[1]Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140 (3) :519-527.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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