GSK-3β inhibitor 22

GSK-3β inhibitor 22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM. GSK-3β inhibitor 22 has the potential of the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[1005199-84-7]

UNSPSC

12352005

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-3β-inhibitor-22.html

Concentration

10mM

Purity

99.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(C1=CC(CSC2=NN=C(C3=CC4=C(N=CS4)C=C3)O2)=CC=C1OC)F

Molecular Formula

C18H12F3N3O2S2

Molecular Weight

423.43

References & Citations

[1]Morihisa Saitoh, et al. Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. Bioorg Med Chem. 2009 Mar 1;17 (5) :2017-29.