A-1165442

A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1.

Product Specifications

CAS Number

[1221443-94-2]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/A-1165442.html

Purity

99.92

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=CC=CC2=C1C=C(C)N=C2)N[C@H]3C4=CC=C(Cl)C=C4OC(CF)(CF)C3

Molecular Formula

C22H20ClF2N3O2

Molecular Weight

431.86

References & Citations

[1]Voight EA, et al. Discovery of (R) -1- (7-chloro-2,2-bis (fluoromethyl) chroman-4-yl) -3- (3-methylisoquinolin-5-yl) urea (A-1165442) : a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. J Med Chem. 2014 Sep 11;57 (17) :7412-24.